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M. leprae infects respiratory tract cells in vivo. C57BL/6 mice were intranasally challenged with M. leprae. Airway and lungs were monitored by histological examination for detection of bacteria and lesions. The images show terminal bronchiole and circumjacent lung tissue after 4 h of infection. Acid-fast bacilli (arrows) in luminal macrophages (A) and in shed epithelial cells (B) are shown. Bars, 10 μm (A) and 5 μm (B).
