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. 2013 Jul;51(7):2371–2378. doi: 10.1128/JCM.00157-13

Table 2.

MIC90 and antimicrobial susceptibility for Gram-positive isolates collected from pediatric patients as part of TEST 2004–2011a

Species and antimicrobial agent Africa
 Asia-Pacific Rim
 Europe
 Latin America
 Middle East
 North America
 Global
MIC90 % S MIC90 % S MIC90 % S MIC90 % S MIC90 % S MIC90 % S MIC90 % S
Staphylococcus aureus
    AMOX-CLAV ≥16 84.0 ≥16 70.5 4 91.3 ≥16 67.7 4 90.4 8 68.6 8 78.5
    Ampicillin ≥32 4.0 ≥32 6.0 ≥32 16.6 ≥32 7.7 ≥32 9.6 ≥32 9.1 ≥32 11.5
    Ceftriaxone ≥128 83.0 ≥128 68.9 16 89.5 ≥128 66.9 16 87.5 32 65.3 32 76.3
    Imipenem 16 81.3 1 92.9 0.5 97.7 ≥32 84.2 — — 1 97.5 1 95.9
    Levofloxacin 0.5 90.0 8 76.5 1 90.8 8 76.8 1 91.2 4 79.6 4 84.1
    Linezolid 2 100 4 100 4 100 4 100 4 100 2 100 4 100
    Meropenem 2 91.2 ≥32 75.9 1 96.3 ≥32 80.1 2 94.1 2 95.6 2 92.4
    Minocycline 4 98.0 4 91.3 0.5 98.3 0.5 98.5 1 99.3 ≤0.25 99.3 0.5 98.4
    Penicillin ≥16 4.0 ≥16 6.0 ≥16 14.4 ≥16 5.8 ≥16 8.1 ≥16 7.7 ≥16 9.8
    PIP-TAZ ≥32 86.0 ≥32 72.7 4 94.0 ≥32 72.5 8 92.6 ≥32 75.8 ≥32 83.1
    Tigecycline 0.25 100 0.25 100 0.25 100 0.25 100 0.25 100 0.25 100 0.25 100
    Vancomycin 1 100 1 100 1 100 1 100 1 100 1 100 1 100
Streptococcus pneumoniae
    AMOX-CLAV 4 80.6 8 74.6 2 94.8 2 93.0 2 90.1 4 83.3 4 88.9
    Ampicillin 4 NA 8 NA 2 NA 4 NA 4 NA 8 NA 4 NA
    Ceftriaxone 1 93.9 2 78.0 1 94.9 1 93.8 1 91.8 1 93.2 1 93.1
    Imipenem 0.5 32.0 0.5 85.2 0.25 89.2 1 74.4 — — 0.5 63.3 0.5 70.2
    Levofloxacin 1 100 1 99.4 1 99.8 1 99.4 1 98.9 1 99.7 1 99.7
    Linezolid 1 99.0 1 100 1 100 1 100 1 100 1 100 1 >99.9
    Meropenem 1 56.2 1 47.3 0.5 83.4 1 75.4 1 73.2 1 70.7 1 75.5
    Minocycline 8 78.6 ≥16 38.2 ≥16 66.7 ≥16 69.1 ≥16 57.7 8 77.5 ≥16 69.2
    Penicillin 4 14.3 4 37.0 2 65.6 2 47.2 4 43.4 4 49.7 4 53.9
    PIP-TAZ 4 NA 8 NA 4 NA 4 NA 4 NA 4 NA 4 NA
    Tigecycline 0.03 96.9 0.03 100 0.06 98.3 0.06 98.3 0.03 99.5 0.06 98.6 0.06 98.5
    Vancomycin 0.5 100 0.5 100 0.5 100 0.5 100 0.5 100 0.5 100 0.5 100
Streptococcus agalactiae
    AMOX-CLAV 0.12 NA 0.12 NA 0.12 NA 0.12 NA 0.12 NA 0.12 NA 0.12 NA
    Ampicillin 0.12 100 0.25 100 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100
    Ceftriaxone 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100
    Imipenem — — — — 0.25 NA — — — — 0.25 NA 0.25 NA
    Levofloxacin 1 96.3 1 98.0 1 99.8 1 99.0 1 100 1 100 1 99.6
    Linezolid 1 100 2 100 1 100 2 100 1 100 1 100 1 100
    Meropenem ≤0.12 100 ≤0.12 100 ≤0.12 100 ≤0.12 100 ≤0.12 100 ≤0.12 100 ≤0.12 100
    Minocycline ≥16 3.7 ≥16 22.4 ≥16 14.6 ≥16 18.1 ≥16 17.2 ≥16 16.6 ≥16 15.9
    Penicillin 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100 0.12 100
    PIP-TAZ ≤0.25 NA 0.5 NA 0.5 NA 0.5 NA 0.5 NA ≤0.25 NA 0.5 NA
    Tigecycline 2 88.9 0.06 98.0 0.12 99.5 0.06 100 0.25 100 0.12 99.5 0.12 99.2
    Vancomycin 0.5 100 1 100 0.5 100 0.5 100 1 100 0.5 100 0.5 100
Enterococcus faecalis
    AMOX-CLAV 1 NA 1 NA 1 NA 1 NA 1 NA 1 NA 1 NA
    Ampicillin 1 100 2 100 2 99.3 2 100 2 100 1 99.8 2 99.6
    Ceftriaxone ≥128 NA ≥128 NA ≥128 NA ≥128 NA ≥128 NA ≥128 NA ≥128 NA
    Imipenem — — — — 4 NA — — — — 4 NA 4 NA
    Levofloxacin ≥64 48.4 32 77.3 4 88.9 32 81.7 32 86.2 2 92.4 16 87.4
    Linezolid 2 100 2 97.7 2 100 2 100 2 100 2 99.8 2 99.8
    Meropenem — — 16 NA 8 NA 8 NA 8 NA 8 NA 8 NA
    Minocycline ≥16 32.3 ≥16 40.9 ≥16 34.6 ≥16 30.0 ≥16 34.5 ≥16 34.0 ≥16 33.8
    Penicillin 4 100 4 100 4 99.3 4 98.9 4 100 4 99.8 4 99.5
    PIP-TAZ 4 NA 8 NA 8 NA 8 NA 4 NA 4 NA 4 NA
    Tigecycline 0.25 100 0.25 100 0.25 100 0.25 100 0.25 100 0.25 99.0 0.25 99.6
    Vancomycin 2 100 2 100 2 99.8 2 100 2 100 2 99.0 2 99.6
Enterococcus faecium
    AMOX-CLAV — — ≥16 NA ≥16 NA ≥16 NA — — ≥16 NA ≥16 NA
    Ampicillin — — ≥32 10.0 ≥32 28.9 ≥32 24.1 — — ≥32 37.5 ≥32 28.1
    Ceftriaxone — — ≥128 NA ≥128 NA ≥128 NA — — ≥128 NA ≥128 NA
    Imipenem — — — — — — — — — — ≥32 NA ≥32 NA
    Levofloxacin — — ≥64 6.7 ≥64 38.6 ≥64 27.6 — — ≥64 33.8 ≥64 31.5
    Linezolid — — 2 100 2 98.8 2 100 — — 2 95.0 2 98.1
    Meropenem — — ≥32 NA ≥32 NA ≥32 NA — — ≥32 NA ≥32 NA
    Minocycline — — 8 70.0 ≥16 61.4 ≥16 56.9 — — 8 76.3 ≥16 66.7
    Penicillin — — ≥16 10.0 ≥16 25.3 ≥16 20.7 — — ≥16 35.0 ≥16 25.1
    PIP-TAZ — — ≥32 NA ≥32 NA ≥32 NA — — ≥32 NA ≥32 NA
    Tigecycline — — 0.12 100 0.25 100 0.25 100 — — 0.12 100 0.25 100
    Vancomycin — — ≥64 83.3 4 90.4 ≥64 53.4 — — ≥64 57.5 ≥64 71.9
a

MIC90s are expressed in milligrams per liter. Abbreviations and symbols: % S, % of isolates susceptible; AMOX-CLAV, amoxicillin-clavulanate; PIP-TAZ, piperacillin-tazobactam; NA, susceptibility breakpoint not available; —, n is <20, and therefore, MIC90 and % S are not given.