Table 2.
Types of infection caused by amoxicillin-clavulanate acid-resistant E. coli isolates according to mechanism of resistancea
| Infection | % of patients (95% CI) harboring isolate with mechanism of resistance |
|||||
|---|---|---|---|---|---|---|
| All cases (n = 212) | HPen (n = 54) | IRT (n = 43) | c-AmpC (n = 40) | p-AmpC (n = 40) | OXA-1 (n = 35) | |
| Urinary tract | 67 (60–73) | 46 (34–59) | 79 (65–88) | 65 (49–78) | 67 (52–80) | 86 (71–94) |
| Asymptomatic bacteriuria | 5 (3–10) | 0 (0–7) | 5 (1–15) | 7 (2–20) | 15 (7–29) | 3 (0–14) |
| Cystitis | 59 (53–66) | 44 (32–58) | 74 (60–85) | 55 (40–69) | 50 (35–65) | 80 (64–90) |
| Pyelonephritis/prostatitis | 2 (1–5) | 2 (0–10) | 0 (0–8) | 2 (0–13) | 2 (0–13) | 3 (0–14) |
| Intra-abdominal infection | 7 (4–12) | 17 (9–29) | 5 (1–15) | 5 (1–16) | 2 (0–13) | 6 (1–19) |
| Skin and soft tissue infection | 14 (10–19) | 28 (18–41) | 9 (4–21) | 7 (2–20) | 12 (5–26) | 6 (1–19) |
| Respiratory tract infection | 3 (1–6) | 2 (0–10) | 5 (1–15) | 5 (1–16) | 2 (0–13) | 0 (0–10) |
| Primary bacteremia | 4 (2–7) | 2 (0–10) | 0 (0–8) | 10 (4–23) | 5 (1–16) | 3 (0–14) |
| Others | 5 (3–9) | 6 (2–15) | 2 (0–12) | 7 (2–20) | 10 (4–23) | 0 (0–10) |
| Bacteremia (primary or secondary) | 7 (5–12) | 6 (2–15) | 2 (0–12) | 15 (7–29) | 5 (1–16) | 11 (4–30) |
a
HPen, TEM-1 or SHV-1 hyperproducer; IRT, inhibitor-resistant TEM producer; c-AmpC, chromosomal AmpC hyperproducer; p-AmpC, plasmidic AmpC producer; OXA-1, OXA-1 producer.