Figure 1. Inducible Nkx2.1 expression in mESCs.
A. Schematic of the iNkx2.1 mESC line. B. Fluorescent in situ hybridization (FISH) of iNkx2.1 line demonstrating a single Lhx6∷GFP BAC insertion in chromosome 1 (with the native Lhx6 gene on chromosome 2). C. iNkx2.1 mESCs were cultured for 2 days, treated with Dox for 24 hours, and then fixed. Nearly all iNkx2.1 ESCs express Nkx2.1. Scale bar = 50 μm.