Skip to main content
. Author manuscript; available in PMC: 2014 Jun 10.
Published in final edited form as: Cancer Cell. 2013 May 23;23(6):725–738. doi: 10.1016/j.ccr.2013.04.009

Figure 1. Expression of an alveolar-like gene module correlates with lung ADC patient outcome.

Figure 1

(A) Hierarchical clustering was performed on primary ADCs from the NCI Director's Challenge Cohort (DCC; n=442) based on 249 genes that mark AT2 cell differentiation and airway homeostasis. The heatmap represents tumors clustered into “DASC-like” or “alveolar-like” subsets.

(B) Gene set enrichment analysis showing the similarities between activated genes in “DASC-like” tumors and distal airway stem cells. NES=normalized enrichment score.

(C) Frequency of poorly, moderately, or well differentiated stage I tumors within the “alveolar-like” and “DASC-like” groups.

(D) Normalized log2 expression values of epithelial lineage markers in stage I ADCs in DCC tumors. Data presented as a Box-whisker plot (5-95%). p-values calculated by Student's t-test with Bonferroni correction. ns=not significant.

(E) Kaplan-Meier curves for the overall survival of DCC patients classified as in (A). p-values calculated by log-rank test.

(F) NSCLCs from the Duke Medical Center were classified as in (A), and survival plotted for patients with ADC (green and red curves) versus SCC (black and grey curves). p-values calculated by log-rank test.

See also Figure S1 and Table S1.