Table 1: Body of Evidence Examined According to Study Design.

Study Design	Number of Eligible Studies
RCT Studies
Systematic review of RCTs Large RCT Small RCT	4
Observational Studies
Systematic review of non-RCTs with contemporaneous controls Non-RCT with non-contemporaneous controls Systematic review of non-RCTs with historical controls Non-RCT with historical controls Database, registry, or cross-sectional study Case series Retrospective review, modelling Studies presented at an international conference Expert opinion Total	4

Abbreviation: RCT, randomized controlled trial.