Table 5: ICER of TAVI Versus sAVR in 3-Way Sensitivity Analysesa.
|
Increment in Utility (TAVI Versus sAVR) |
Difference in Total Cost of TAVI Versus sAVR | |||
|---|---|---|---|---|
|
-$4,642 (Base Case) |
$5,358 | $15,358 | $25,358 | |
| Life Table Mortality After 1 Year for Both TAVI and sAVR (Base Case) | ||||
| 0 | $46,970b | Dominated | Dominated | Dominated |
| 0.01 (base-case) | $66,985b | Dominated | Dominated | Dominated |
| 0.06 | Dominant | $77,904 | $223,313 | $368,722 |
| 0.12 | Dominant | $22,665 | $64,970 | $107,275 |
| Mortality After 1 Year of 0.25 for Both TAVI and sAVR | ||||
| 0 | $182,700a | Dominated | Dominated | Dominated |
| 0.01 | $588,373a | Dominated | Dominated | Dominated |
| 0.06 | Dominant | $39,465 | $141,646 | $243,827 |
| 0.12 | Dominant | $16,842 | $60,448 | $104,054 |
| Mortality After 1 Year of 0.25 for SAVR and 0.24 for TAVI | ||||
| 0 | Dominant | $506,880 | $1,691,211 | $2,875,543 |
| 0.01 | Dominant | $133,845 | $446,574 | $759,303 |
| 0.06 | Dominant | $30,139 | $100,561 | $170,982 |
| 0.12 | Dominant | $15,531 | $51,821 | $88,110 |
Abbreviations: ICER, incremental cost-effectiveness ratio; sAVR, surgical aortic valve replacement; TAVI, transcatheter aortic valve implantation.
a
All amounts are in Canadian dollars.
b
The larger ICER means that TAVI is more cost-effective than sAVR (the results are in the southwest quadrant of the cost-effectiveness plane).