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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Eur J Immunol. 2012 Mar;42(3):672–680. doi: 10.1002/eji.201142071

Figure 6.

Figure 6

Prevention of CD40 signaling in polyclonal NOD CD4 T cells impairs their diabetogenicity. CD4 T cells were isolated from spleen and lymph nodes of diabetic NOD mice and transduced either with GFP alone, CD40 full-length or CD40DN. After in vitro expansion in IL-2, 12.5 × 106 T cells were transferred i.v. into adult NOD.scid recipients and mice were monitored for hyperglycemia. All mice receiving cells transduced with GFP or CD40 full-length (CD40hi) became diabetic whereas in mice transferred with CD40DN cells, diabetes was prevented in 4 of 8 recipients for at least 90 days after transfer (p < 0.01). Data are representative of at least 2 independent experiments.