Table 3.
Subgroup | CEE Trial | CEE+MPA Trial | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||
CEE | Placebo | P† | CEE+MPA | Placebo | P | ||||||||||
N | (%)‡ | N | (%) | HR* | (95% CI) | N | (%) | N | (%) | HR | (95% CI) | ||||
| |||||||||||||||
Active vs. placebo: All participants | 117 | (0.28) | 149 | (0.35) | 0.81 | (0.63, 1.03) | 0.08 | 293 | (0.43 | 221 | (0.34) | 1.25 | (1.05, 1.49) | 0.01 | |
| |||||||||||||||
Breast tenderness at baseline | 0.37 | 0.03 | |||||||||||||
No | 91 | (0.26) | 125 | (0.35) | 0.75 | (0.57, 0.98) | 246 | (0.41) | 199 | (0.35) | 1.17 | (0.97, 1.41) | |||
Yes | 24 | (0.34) | 23 | (0.31) | 1.00 | (0.56, 1.79) | 45 | (0.56) | 20 | (0.27) | 2.16 | (1.29, 3.74) | |||
Breast tenderness at baseline by prior MHT§ | 0.13 | 0.04 | |||||||||||||
No breast tenderness/No prior MHT | 42 | (0.23) | 75 | (0.42) | 0.56 | (0.38, 0.82) | 176 | (0.40) | 160 | (0.38) | 1.05 | (0.85, 1.30) | |||
No breast tenderness/prior MHT | 49 | (0.29) | 50 | (0.29) | 1.02 | (0.69, 1.52) | 70 | (0.45) | 39 | (0.27) | 1.63 | (1.11, 2.44) | |||
Breast tenderness/No prior MHT | 15 | (0.40) | 14 | (0.39) | 1.02 | (0.49, 2.15) | 31 | (0.55) | 13 | (0.24) | 2.29 | (1.21, 4.56) | |||
Breast tenderness/prior MHT | 9 | (0.27) | 9 | (0.24) | 1.09 | (0.42, 2.80) | 14 | (0.58) | 7 | (0.32) | 1.80 | (0.74, 4.76) | |||
Severity of Breast tenderness at baseline | 0.53 | 0.02 | |||||||||||||
No breast tenderness | 91 | (0.26) | 125 | (0.35) | 0.75 | (0.57, 0.98) | 246 | (0.41) | 199 | (0.35) | 1.17 | (0.97, 1.41) | |||
Mild tenderness | 20 | (0.36) | 18 | (0.30) | 1.14 | (0.60, 2.17) | 37 | (0.54) | 18 | (0.28) | 1.96 | (1.13, 3.54) | |||
Moderate/severe tenderness | 4 | (0.27) | 5 | (0.37) | 0.64 | (0.16, 2.43) | 8 | (0.70) | 2 | (0.19) | 4.55 | (1.09, 30.82) |
Hazard ratio from Cox proportional hazards models stratified by age, WHI Dietary Modification Trial treatment assignment, and subgroup.
P-values for main effect of treatment (boldface) and for interaction between treatment assignment and subgroup.
Annualized percentage.
MHT = menopausal hormone therapy