Table III.
Association of combined risk genotypes of p53-related genes with SPM risk after index SCCHN
| Total (n = 1283) | SPM free (n = 1163) | SPM (n = 120) | P a | HR (95% CI)b | P | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | ||||
| No. of risk genotypes | |||||||||
| 0–3 risk genotypes | 463 | 36.1 | 436 | 37.5 | 27 | 22.5 | <0.001 | 1.0 | |
| 4 risk genotypes | 353 | 27.5 | 325 | 27.9 | 28 | 23.3 | 1.5 (0.9–2.5) | 0.155 | |
| 5 risk genotypes | 266 | 20.7 | 238 | 20.5 | 28 | 23.3 | 1.8 (1.1–3.1) | 0.025 | |
| 6 risk genotypes | 141 | 11.0 | 122 | 10.5 | 19 | 15.9 | 2.1 (1.2–3.8) | 0.015 | |
| 7 risk genotypes | 49 | 3.8 | 35 | 3.0 | 14 | 11.7 | 5.5 (2.8–10.9) | <0.0001 | |
| 8–9 risk genotypes | 11 | 0.9 | 7 | 0.6 | 4 | 3.3 | 7.1 (2.4–21.0) | 0.0004 | |
| Trend | <0.001 | ||||||||
| Combined risk genotypesc | |||||||||
| Low-risk group | 463 | 36.1 | 436 | 37.5 | 27 | 22.5 | <0.001 | 1.0 | |
| Medium-risk group | 619 | 48.2 | 563 | 48.4 | 56 | 46.7 | 1.6 (1.0–2.6) | 0.039 | |
| High-risk group | 201 | 15.7 | 164 | 14.1 | 37 | 30.8 | 3.0 (1.8–5.0) | <0.0001 | |
| Trend | <0.001 | ||||||||
aChi-square test for differences in the distribution of genotypes in p53-related genes between the patients who developed SPM and the patients who did not.
bAdjusted for age, sex, ethnicity, tobacco smoking and alcohol drinking in a Cox model.
cLow-risk group, individuals carrying 0–3 risk genotypes; medium-risk group, individuals carrying 4–5 risk genotypes; high-risk group, individuals carrying 6–9 risk genotypes.