Table 4.
Complement regulators in multiple sclerosis disease subgroups and controls.
| C1 inhibitor mg/l |
p | p* | Clusterin mg/l |
Factor H mg/l |
p | p* | Factor I mg/l |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | Mean | SD | No. | Mean | SD | No. | Mean | SD | No. | Mean | SD | |||||
| Control | 35 | 288.06 | 48.26 | N/A | <0.001 | 35 | 52.74 | 23.09 | 35 | 212.94 | 63.08 | N/A | 0.007 | 35 | 29.42 | 7.95 |
| Total MS | 140 | 356.79 | 68.48 | <0.001 | N/A | 82 | 57.69 | 21.01 | 176 | 278.05 | 79.08 | <0.001 | N/A | 140 | 29.97 | 6.86 |
| S-RRMS | 37 | 350.94 | 64.53 | 0.002 | 1.000 | 20 | 55.48 | 14.90 | 37 | 238.90 | 78.52 | 1.000 | 0.719 | 37 | 28.23 | 8.34 |
| A-RRMS | 32 | 368.44 | 87.55 | <0.001 | N/A | 20 | 67.22 | 23.09 | 68 | 267.04 | 60.17 | 0.007 | N/A | 32 | 29.30 | 6.08 |
| SPMS | 34 | 369.06 | 63.62 | <0.001 | 1.000 | 22 | 56.99 | 23.72 | 34 | 341.94 | 71.60 | <0.001 | <0.001 | 34 | 29.60 | 5.99 |
| PPMS | 37 | 340.29 | 53.60 | 0.013 | 0.777 | 20 | 51.13 | 18.91 | 37 | 274.11 | 77.26 | 0.003 | 1.000 | 37 | 32.66 | 6.21 |
SD, standard deviation. p-values are measured using students t-test to compare MS and controls and ANOVA for multiple comparisons. p-values are shown for the subgroup analysis if a significant difference was seen at ANOVA. p = comparison with control group. p* = comparison with A-RRMS group. S-RRMS, stable relapsing–remitting MS with no relapses reported for at least 12 months; A-RRMS, acute relapsing–remitting MS sampled in relapse; SPMS, secondary progressive MS; PPMS, primary progressive MS.