Table 1. Baseline characteristics of participants by plasma 25(OH)D levels.
| Characteristic | Plasma 25(OH)D | p value for trend | ||
|---|---|---|---|---|
| < 20 ng/ml (n = 228) |
20 – 30 ng/ml (n = 162) |
> 30 ng/ml (n = 105) |
||
| Age (years) | 68 ± 12 | 71 ± 12 | 72 ± 10 | 0.0016 |
| Sex (% Male) | 98.2 | 98.8 | 99.0 | 0.54 |
| Race (% Black) | 39.5 | 18.2 | 14.6 | < 0.0001 |
| CVD (%) | 44.7 | 50.6 | 61.9 | 0.004 |
| Hypertension (%) | 95.6 | 95.7 | 93.3 | 0.43 |
| Current smoking (%) | 62.1 | 42.7 | 39.1 | 0.004 |
| Alcoholic drinks per week | 1.30 ± 3.6 | 1.50 ± 5.3 | 0.73 ± 2.2 | 0.34 |
| Treatment arm of HOST (%) | 49.6 | 46.9 | 52.4 | 0.76 |
| BMI (kg/m2) | 26.8 ± 4.3 | 26.6 ± 4.8 | 26.0 ± 4.0 | 0.14 |
| SBP (mmHg) | 140 ± 22 | 140 ± 21 | 138 ± 18 | 0.53 |
| DBP (mmHg) | 75 ± 13 | 73 ± 13 | 72 ± 11 | 0.059 |
| MDRD-eGFR (ml/min/1.73 m2) | 17.7 ± 6.6 | 17.9 ± 6.6 | 19.4 ± 6.7 | 0.04 |
| Albumin (g/dl) | 4.1 ± 0.4 | 4.2 ± 0.4 | 4.2 ± 0.5 | 0.0006 |
| Phosphorus (mg/dl) | 4.2 ± 1.2 | 4.3 ± 2.1 | 4.1 ± 1.0 | 0.68 |
| Calcium (mg/dl) | 8.9 ± 0.7 | 8.9 ± 0.7 | 9.0 ± 0.6 | 0.27 |
| 1,25(OH)2D (pg/ml) | 17.7 ± 8.1 | 24.2 ± 12.6 | 27.7 ± 12.4 | < 0.0001 |
| iPTH (pg/ml) | 225 ± 180 | 158 ± 120 | 144 ± 123 | < 0.0001 |
| FGF-23 (RU/ml) | 1,212 ± 3,050 | 793 ± 1,024 | 873 ± 2,252 | 0.14 |
| Total cholesterol (mg/dl) | 181 ± 43 | 176 ± 38 | 164 ± 37 | 0.0006 |
| Triglycerides (mg/dl) | 197 ± 180 | 169 ± 95 | 142 ± 71 | 0.0006 |
| LDL-C (mg/dl) | 100 ± 33 | 99 ± 33 | 93 ± 31 | 0.13 |
| HDL-C (mg/dl) | 45 ± 19 | 44 ± 16 | 43 ± 11 | 0.32 |
Values are expressed as mean ± standard deviation unless otherwise specified. CVD = cardiovascular disease; BMI = body mass index; SBP = systolic blood pressure; DBP = diastolic blood pressure; MDRD-GFR = glomerular filtration rate calculated using the Modification of Diet in Renal Disease formula; TG = triglyceride; LDL = low density lipoprotein cholesterol; HDL = high density lipoprotein cholesterol; Calcium = albumin-adjusted serum calcium; 25(OH)D = 25-hydroxyvitamin D; 1,25(OH)2D = 1,25-dihydroxyvitamin D; FGF-23 = fibroblast growth factor 23; iPTH = intact parathyroid hormone.