Figure 2.

Synthesis and export of Wnt ligand. Wnt ligand undergoes multiple posttranslational modifications in the ER. Glycosylation and palmitoylation of Wnt ligand (the latter mediated by the transmembrane protein Porc) are required for its translocation to the Golgi apparatus. Palmitoylation of Wnt allows it to bind Wls, which provides a mechanism for transportation to the plasma membrane. The retromer complex recycles Wls from the plasma membrane back to the Golgi.