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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Cancer Invest. 2012 Apr 5;30(4):275–286. doi: 10.3109/07357907.2012.657814

Figure 1.

Figure 1

Progastrin exerts significant proliferative effects on the colonic epithelia leading to ACF formation. (A) Representative pictures of the three different types of ACF (A1-single, A2-double, and A3-multiple crypts) observed in the colon of AOM-treated mice. Colons were removed 3 weeks after being treated with AOM, fixed with ethanol overnight and analyzed for aberrant crypts after methylene blue staining (×200). (B) Multiplicity of ACF across the four groups. (*p < .03, **p < .003). (C) Average number of ACF seen in all the four study groups (N = 4 pergroup). All values represent the mean ± SD. (*p < .02)