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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Cancer Invest. 2012 Apr 5;30(4):275–286. doi: 10.3109/07357907.2012.657814

Figure 2.

Figure 2

Inactivation of the p53 gene accelerates progastrin-dependent colonic proliferation (BrdU-Labeling Index). (A) Table showing the different rates of BrdU-labeling indices among the four study groups compared with their respective controls, and also shows the difference in proliferation rates between the tumor area and uninvolved area of the colon in AOM treated C57Bl6 mice. (B) Graphical representation of the percentage labeling indices across the four study groups. (∞ p = .46; *p < .03; **p < .01). (C) Graphical comparison of the LI of tumor area and uninvolved areas of the colon in the study groups (∞ p = .46, *p < .03). (D) Photographs showing immunohistochemical staining of BrdU positive cells in the colon from tumor area (1) and normal crypt (2) of an AOM injected hGAS/p53RH double mutant mouse.