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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Cancer Invest. 2012 Apr 5;30(4):275–286. doi: 10.3109/07357907.2012.657814

Figure 5.

Figure 5

Progastrin overexpression promotes the expression of colonic cells positive for DCAMKL-1. (A) The average percentage of DCAMKL-1 positive cells in the colon crypts of the study groups observed per high power field (400×) in each of the four groups of mice (n = 4 per group). All values represent the mean ± SD (*p < .03). (B) Immunohistochemistry for DCAMKL-1 in colonic mucosa and colon tumors in mice from each group treated with AOM (hGAS; hGAS/p53RH; p53RH and WT mice). Representative results from four different groups are shown in different magnifications: (a) hGAS mouse colon showing crypt fission and DCAMKL-1 positive cells (400×). (b) Expression of the progenitor cells is seen in an hGAS mouse colon tumor (200×). (c) DCAMKL-1 positive cells are present in the hyper-proliferative epithelium of hGAS/p53RH double mutant mouse (400×). (d) Colon tumor in hGAS/p53RH colon showing abundance of DCAMKL-1 positivity (200×). (e) WT uninvolved mucosa showing a single cellular DCAMKL-1 expression, and (f) shows a colon tumor in AOM treated WT animal with low DCAMKL-1 positivity.