Figure 5.
Among-line covariance of gene expression and competitive fitness in Drosophila is modular. (A–C) Genetic (among-line) architecture of 414 gene expression traits measured in adult flies of 40 wild-caught lines (Ayroles et al. 2009). (A) Posterior mean broad-sense heritabilities (H2) of the 414 genes. (B) Heat map of posterior mean genetic correlations among these genes. (C) Posterior mean estimates and 95% highest posterior density (HPD) intervals for genetic correlations between each gene and competitive fitness. For comparison, see Ayroles et al. (2009, Figure 7a). (D–F) Latent trait structure underlying gene expression covariances. (D) Posterior mean H2 for each estimated latent trait. (E) Heat map of posterior mean Λ matrix showing gene loadings on each latent trait. (F) Posterior mean estimates and 95% HPD intervals for genetic correlations between each latent trait and competitive fitness. The right axis of E groups genes into modules inferred using modulated modularity clustering (Ayroles et al. 2009; Stone and Ayroles 2009).