Table 2. Power of different methods in a disease model in which only rare variants (MAF ≤ 1%) are causal with relative risk of 5 (c_i = 0.2).

Error rate	Coverage per person	C-alpha	Freq-weight	VT	RWAS	LRT_G	VST	LRT
0	4	0.731	0.786	0.879	0.425	0.6	0.473	0.867
	10	0.778	0.801	0.898	0.43	0.623	0.481	0.872
	20	0.782	0.806	0.896	0.433	0.631	0.489	0.866
0.01	4	0.5	0.68	0.802	0.376	0.524	0.257	0.838
	10	0.759	0.809	0.898	0.446	0.628	0.479	0.896
	20	0.784	0.815	0.908	0.438	0.621	0.475	0.887

Tested methods were C-alpha (Neale et al. 2011), Freq-weight similar to the Madsen–Browning method (Madsen and Browning 2009), variable threshold (VT) (Price et al. 2010), RWAS (Sul et al. 2011b), LRT_G (Sul et al. 2011a), and our proposed methods (VST and LRT).