Table 3.

Relative hazards (95% CI) forall-causemortality by solute

Solute	Overall (continuous, per 1 SD)	Hazard ratio (95% CI)
		Below median		Above median
P-cresol sulfate
Range of values	0-11.1 mg/dl (SD = 1.76 mg/dl)	0-3.1 mg/dl		3.1-11.1 mg/dl
Unadjusted	1.05 (0.93-1.17)	Reference		1.10 (0.88-1.37)
Adjusted*	1.02 (0.90-1.16)	Reference		1.03 (0.81-1.31)
+ obesity, creatinine	1.02 (0.90-1.16)	Reference		1.03 (0.83-1.28)
Indoxyl sulfate
Range of values	0-6.8 mg/dl (SD = 1.11 mg/dl)	0-1.6 mg/dl		1.6-6.8 mg/dl
Unadjusted	0.93 (0.84-1.04)	Reference		1.03 (0.83-1.28)
Adjusted*	0.98 (0.87-1.10)	Reference		1.14 (0.90-1.44)
+ obesity, creatinine	1.04 (0.91-1.18)	Reference		1.30 (1.01-1.69)
MMA
Range of values	24.2-190.6 ug/L (SD = 16.48 ug/L)	24.2-49.6 ug/L		49.7-190.6 ug/L
Unadjusted	1.10 (0.99-1.23)	Reference		1.01 (0.81-1.26)
Adjusted*	1.05 (0.94-1.17)	Reference		0.94 (0.74-1.20)
+ obesity, creatinine	1.09 (0.97-1.22)	Reference		1.00 (0.78-1.29)
DMA
Range of values	7.6-33.9 uM (SD = 3.69 uM)	7.6-18.3 uM		18.3-33.9 uM
Unadjusted	0.96 (0.86-1.07)	Reference		0.86 (0.69-1.08)
Adjusted*	1.00 (0.89-1.12)	Reference		0.88 (0.69-1.11)
+ obesity, creatinine	1.01 (0.90-1.14)	Reference		0.91 (0.71-1.17)
Total Score (vs. 0)**	Continuous	1	2	3	4
Unadjusted	1.00 (0.91-1.09)	1.53 (1.03-2.27)	1.24 (0.87-1.77)	1.21 (0.83-1.77)	1.14 (0.72-1.79)
Adjusted*	0.99 (0.89-1.10)	1.28 (0.85-1.94)	1.24 (0.85-1.80)	0.96 (0.64-1.43)	1.26 (0.78-2.04)
+ obesity, creatinine	1.04 (0.93-1.16)	1.29 (0.84-1.99)	1.28 (0.86-1.90)	1.06 (0.69-1.64)	1.49 (0.88-2.51)

All models stratified by clinic cluster. *Adjustment: basic model, age at enrollment, sex, race, comorbidity score (ICED), and baseline albumin: + obesity and creatinine value. **Total number of solutes with levels above the population median.