Table 7.
Cost of multiple sclerosis disease (MS) and interferon beta (INF β) therapy
|
Cost per patient per year ($) |
RRMS 1-3.5 |
RRMS 4-6 |
RRMS 6< |
SPMS 4-6 |
SPMS 6< |
|
|---|---|---|---|---|---|---|
| Total costs for other medications is related to” Interferons-beta” administration and duration, EDSS and type of disease | ||||||
|
Total medical direct cost (Medicines) |
||||||
| Interferon beta-1a (Avonex)* |
9861 |
9861 |
0 |
9861 |
0 |
|
| Interferon beta-1a (Rebif)* |
7106 |
7106 |
0 |
7106 |
0 |
|
| Interferon beta-1b (Betaferon)* |
9176 |
9176 |
0 |
9176 |
0 |
|
| Interferon beta-1a IM (CBPs)* |
3762 |
3762 |
0 |
3762 |
0 |
|
| Interferon beta-1a SC (CBPs)* |
5873 |
5873 |
0 |
5873 |
0 |
|
| Interferon beta-1b (CBPs & BS)* |
7969 |
7969 |
0 |
7969 |
0 |
|
| Antidepressant medications |
The first 3 cycles |
2.3 |
2.7 |
3.2 |
2.7 |
3.2 |
| Other Cycles |
1.5 |
1.8 |
2.2 |
1.8 |
2.2 |
|
| Anti-spasm medications |
11.65 |
11.65 |
11.65 |
11.65 |
11.65 |
|
| Anti-fatigue medications |
1.36 |
1.36 |
1.36 |
1.36 |
1.36 |
|
| Pain killer medications |
4.7 |
6.6 |
9.8 |
23.5 |
29.9 |
|
| NSAIDs (control SE) |
for Interferon beta-1a IM |
0.15 |
0.15 |
0 |
0.15 |
0 |
| for Interferon beta-1a SC |
0.42 |
0.42 |
0 |
0.42 |
0 |
|
| for Interferon beta-1b |
0.53 |
0.53 |
0 |
0.53 |
0 |
|
|
Other medical direct cost (total) |
167 |
316 |
1543 |
316 |
1543 |
|
| Laboratory tests |
13 |
13 |
0 |
13 |
0 |
|
| Imaging |
103 |
103 |
0 |
103 |
0 |
|
| Physicians visits |
45 |
32 |
14 |
32 |
14 |
|
| Physiotherapy |
0 |
15 |
326 |
15 |
326 |
|
| Psychotherapy |
6 |
64 |
0 |
64 |
0 |
|
| Nursing |
0 |
41 |
816 |
41 |
816 |
|
| Cane, walker, wheelchair, Medical bed, Medical wave mattress |
0 |
48 |
387 |
48 |
387 |
|
|
Non-medical direct cost (total) |
266 |
1841 |
3037 |
1841 |
3037 |
|
| Transport |
266 |
373 |
40 |
373 |
40 |
|
| House reconstructions |
0 |
0 |
1529 |
0 |
1529 |
|
| Car rebuilding |
0 |
1468 |
1468 |
1468 |
1468 |
|
|
Indirect cost (total) |
90 |
130 |
616 |
379 |
740 |
|
| Absence from work |
71 |
120 |
0 |
65 |
0 |
|
| Unemployment or early retirement |
7 |
0 |
616 |
308 |
740 |
|
| Mortality |
12 |
10 |
0 |
6 |
0 |
|
|
Cost per patient per relapse (total) |
33 |
33 |
33 |
54 |
54 |
|
| Medical treatment |
27 |
27 |
27 |
45 |
45 |
|
| Hospitalization | 6 | 6 | 6 | 9 | 9 | |
$ US Dollars 2012, IM intramuscular, SC subcutaneous, NSAIDs non steroid anti- inflammatory drugs, *Cost of injection is included for interferons beta; CBPs Copied biopharmaceuticals including IM IFNβ-1a (Cinnovex, Actovex), SC IFNβ-1a (Recigen, Actorif ) and SC IFNβ-1b (Ziferon, Actoferon), BS biosimilar including SC IFNβ-1b (Extavia).