Figure 4.

Local sensitivity analysis at the steady states of the species involved with respect to all model parameters. The sensitivity matrix denotes the normalized sensitivity coefficients of all species in the model across 20 hours. The sensitivity of the parameters k₁, k₂ (associated in the internalization of external galactose and in activation of Gal3p protein), k₅ (basal expression of transcription factor Gal4p), k₇, k₈, k₉ (associated in the feedback control), μ₁₃, μ₁₆ and μ₁₇ (degradation of Gal3p, internalized galactose and Gal2p proteins, respectively), can more influence the dynamical behavior of this mechanism more than the other parameters.