Table 2. In Vivo Micro-CT Contrast Agents Used to Image Adult Mice.
| Agent | Subject | Contrast in aorta | Concentration (mgI/mL) | Dose | Osmolarity | Persistence | LD50 | Reference |
|---|---|---|---|---|---|---|---|---|
| Isovue | Mouse | 500 HU | 370 | 1 mL/hr, constant infusion | Low | 10 min | 21.8 gI/kg | Badea et al., 2004 |
| Fenestra-VC | Mouse | 620 HU | 50 | 500 μL/25 g | Iso-osmolar | 3 hr | >5,000 mg/kg | Badea et al., 2004 |
| eXIA 160 | Mouse | 900 HU | 20 | 200 μL/20 g | – | 1 hr, 500HU | 25 mL/kg | Prajapati and Keller, 2011 |
| Omnipaque | Mouse | – | 300 | 250 μL | Low | 30 min | 24.2 gI/kg | Paulus et al., 2000 |
| Omnipaque | Chicken embryo | 870 HU | 350 | 10 μL | Low | – | – | Current study |
| Visipaque | Mouse | – | 320 | 8 μL/g | Iso-osmolar | 35 min | 15–20 gI/kg | Almajdub et al., 2008 |
| Visipaque | Chicken embryo | 970 HU | 270 | 15 μL | Iso-osmolar | 3 hr | – | Current study |