Table 1.

Negative selection operates on genes and conserved non-coding (CNCs) regions near genes that are associated with complex diseases. Each cell contains the number of complex disease categories (out of 17) with statistically more negative selection compared to background (and binomial-based p-value for enrichment given the number of diseases tested at the 5% significance level).

	AA	CA	Pooled
CDS	3 (0.009)	2 (0.05)	5 (0.006)
CNCs	1 (0.21)	3 (0.009)	4 (0.03)
Pooled	4 (0.026)	5 (0.006)	9 (0.002)