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(A) Pleomorphic large tumor cells with prominent nucleoli, vesicular chromatin, and scanty cytoplasm are admixed with small numbers of mature lymphocytes. (B) A positive in situ hybridization for EBER in tumor cell nuclei is seen. (C-E) The neoplastic cells are diffusely and strongly positive for the T-cell marker CD3 (C), the B-cell marker CD20 (D), and the cytotoxic molecule TIA-1 (E) (A-E, ×400).
