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Key antigenic determinants on HEV pORF2. a Antigenic and assembly properties of truncated pORF2. b Crystal structure of HEV capsid protein. Crystal structure of T = 1 HEV-VLP (PDB:2ZTN). Mesh representations of dimeric E2s domains highlighted the neutralizing epitopes against several neutralizing monoclonal antibodies. c Key neutralizing epitopes on pORF2. All the identified neutralizing sites were mapped in E2s domain [23, 36, 48, 57, 61]
