Table 1.
Relationship between hepatitis B antigen (HBsAg) level and HBsAg loss in the literature
| Country | Study design | Disease stage | Number of subjects | HBsAg cutoff (IU/mL) | Note | Reference |
|---|---|---|---|---|---|---|
| Taiwan | Cohort | Early HBeAg-negative stage | 390 | 100 | SEARCH-B | [29] |
| Hong Kong | Cohort | HBeAg-negative | 103 | 100 | [32] | |
| Taiwan | Cohort | HBeAg-negative with hepatitis B virus (HBV) DNA level <2000 IU/mL | 688 | 10 | ERADICATE-B (partial) | [30] |
| Taiwan | Case–control | HBeAg-negative | 46–46 | 200 | [35] | |
| Hong Kong | Case–control | HBeAg-negative | 203–203 | 200 | [31] | |
| Taiwan | Cohort | Children | 349 | 1000 | [34] | |
| Taiwan | Cohort | Including HBeAg-positive and -negative | 3466 | 10 | REVEAL-HBV | [33] |