Table 2.
Analysis of the relationship between the proportions of 20:4n-6 and 22:6n-3 in liver and plasma PC and Fads2 mRNA expression and methylation in liver in adult offspring of rats fed diets with differing in fat contents during pregnancy and lactation
| Liver |
Plasma |
Fads2 mRNA | |||||
|---|---|---|---|---|---|---|---|
| 20:4n-6 |
22:6n-3 |
20:4n-6 |
22:6n-3 |
||||
| PC | PE | PC | PE | PC | |||
| r (r2) | |||||||
| Male (n=24) | |||||||
| Fads2 mRNA | 0.57⁎⁎⁎ (0.32) | 0.61⁎⁎⁎ (0.37) | 0.31⁎ (0.1) | 0.54⁎⁎⁎ (0.29) | 0.51⁎⁎ (0.26) | 0.23⁎ (0.05) | |
| CpG −623 | −0.25 | −0.31 | −0.11 | −0.16 | −0.24 | −0.12 | −0.27⁎ (.07) |
| CpG −394 | −0.59⁎⁎ (0.35) | −0.57⁎⁎ (0.32) | −0.32⁎ (0.1) | −0.53⁎⁎ (0.28) | −0.57⁎⁎ (0.32) | −0.43⁎ (0.18) | −0.70⁎⁎⁎⁎ (0.49) |
| CpG −84 | −0.25 | −0.11 | −0.11 | −0.27 | −0.19 | −0.08 | −0.23⁎ (0.05) |
| CpG −76 | −0.1 | −0.22 | −0.08 | −0.19 | −0.23 | −0.29 | −0.15 |
| Female (n=24) | |||||||
| Fads2 mRNA | 0.42⁎ (0.18) | 0.60⁎⁎ (0.36) | 0.32⁎ (0.1) | 0.43⁎⁎ (0.18) | 0.49⁎⁎ (0.24) | 0.55⁎⁎⁎⁎ (0.3) | |
| CpG −623 | −0.17 | 0.12 | −0.15 | −0.17 | −0.23⁎ | −0.27 | −0.34⁎ (0.12) |
| CpG −394 | −0.70⁎⁎⁎⁎ (0.49) | −0.54⁎⁎ (0.29) | −0.27⁎ (0.07) | −0.78⁎⁎ (0.61) | −0.71⁎⁎⁎⁎ (0.5) | −0.63⁎⁎⁎⁎ (0.4) | −0.71⁎⁎⁎⁎ (0.5) |
| CpG −84 | −0.16 | 0.25 | −0.19 | −0.23 | −0.24 | −0.16 | −0.21⁎ (0.04) |
| CpG −76 | −0.20 | −0.19 | −0.412 | −0.19 | −0.14 | −0.26 | −0.01 |
⁎
P<.05.
⁎⁎
P<.01.
⁎⁎⁎
P<.001.
⁎⁎⁎⁎
P<.0001.