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. 2013 Jul;23(7):1097–1108. doi: 10.1101/gr.151670.112

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© 2013, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 2. — Mutation spectra and rates of somatic SNVs. (A) Mononucleotide substitution frequencies by patient. (B) Mononucleotide substitution frequencies by SNV class. (C) Dinucleotide substitution rates of SNVs private to early neoplasias. (D) Dinucleotide substitution rates of SNVs private to carcinomas. (E) Dinucleotide substitution rates of SNVs shared among neoplasias and carcinomas. For C–E, SNVs are pooled across patients. The mutated dinucleotide is indicated in the inner circle, and the substitution occurring within it is color coded. Rate is defined as mutations per dinucleotide of that class.