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. 2013 Jul 1;210(7):1481–1492. doi: 10.1084/jem.20121523

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© 2013 Kodgire et al.

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Figure 6. — Mutation events in the IgL and human β-globin transcription terminator sequences. Mutation events in the 1.1-kb DNA sequence in the active (A) and inactivated (B) terminator knock-in clones. The data are combined mutation numbers for two cell clones for the active and inactivated terminator, respectively. Mutation events in the region upstream of poly(A) site (top) and downstream of poly(A) site (bottom) are analyzed separately. The number of C and G nucleotides, and the number of AID hotspots (WRC and GYW) in the respective regions are shown next to each region. The numbers of transition (ts) and transversion (tv) mutations and their percentages are shown below each region. C/G ratio = ratio of mutations at C and G.