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. 2013 Jul 1;210(7):1331–1350. doi: 10.1084/jem.20120812

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© 2013 Jackstadt et al.

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Figure 1. — Genome-wide analysis of transcriptional regulation by AP4. (A) The indicated human CRC cell lines were subjected to immunoblot analysis to detect expression of the indicated proteins. Detection of α-tubulin served as a loading control. (B) A heat map showing 1,458 differentially regulated mRNAs that displayed a change in expression ≥1.5-fold 0, 12, 24, and 48 h after Ad-AP4 versus Ad-GFP infection of DLD-1 cells is provided (see Table S10 for gene identities). A color scale is shown below. (C and D) Genes displaying >1.5-fold differential regulation after AP4 activation were subjected to Gene Ontology analyses. The results for the functional classes “molecular and cellular processes” (C) or “disease” (D) are shown. Numbers in parentheses indicate the number of genes assigned to the respective category.