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. 2013 Jul 1;210(7):1463–1479. doi: 10.1084/jem.20112495

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© 2013 Iborra et al.

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Figure 9. — Late involvement of mTOR in the induction of Eomes after antigen stimulation. Purified N-ras^+/+ and N-ras^−/− OT-I CD8⁺ T lymphocytes were stimulated in vitro as in Figs. 7 D and 8 and treated or not with rapamycin in the absence (A) or in the presence (B) of IL-12. At the indicated times, cultures were stained for CD45.1 and CD25 for gating and for transcription factors T-bet and Eomes and analyzed by FACS (three experiments for both A and B). Results are expressed as mean ± SEM. Statistical significance is indicated for untreated WT versus N-ras^−/− cells (top asterisks) and for rapamycin treated versus untreated N-ras^−/− cells (bottom asterisks). **, P < 0.005; ***, P < 0.0005.