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Sorafenib reduces collagen production and ECM accumulation in NIH 3T3 cells. After treatment with TGF-β1 and/or sorafenib for 48 h, mouse NIH3T3 fibroblasts were subjected to real-time qPCR for detecting the effects of sorafenib on the transcriptional levels of (a) collagens, (b) TIMP-1 and (c) MMPs. *P<0.05; **P<0.01; as determined using Student's t-test
