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RanBP9 overexpression in APΔE9 mice increases CD68 positive activated microglia at 12 months of age. Immunohistochemical staining of the brain sections from the cortex and the CA1 region of the hippocampus from WT, APΔE9 and APΔE9/RanBP9 mice with CD68 antibody. A representative image for each genotype, all at the same magnification showed relatively more activated microglia in the APΔE9/RanBP9 mice compared with APΔE9 mice and almost complete absence in the WT brains
