Figure 9.

Impaired spatial learning in a T maze paradigm in APΔE9 and APΔE9/RanBP9 transgenic mice at 12 months of age. (a) Analysis of latency in terms of time taken in seconds to reach the T maze arm was plotted against the sessions, one session per day, six trials per session. (b) Percentage of correct responses to reach the goal arm was plotted against the sessions as in a. (c) Analysis of the percentage of correct responses averaged among all the sessions were found to be significantly decreased in APΔE9 mice by 20% and in APΔE9/RanBP9 mice by 36% compared with WT controls. Percentage of errors significantly increased in APΔE9 mice by 21% and in APΔE9/RanBP9 mice by 34%. Repeated measures ANOVA followed by post hoc Tukey–Kramer multiple comparison test revealed significant differences. *P<0.05, **P<0.01 ***P<0.001. The data are mean±S.E.M. and n=6 per genotype