Table 1. Expressional profiles of B4GALT gene family and P-gp, MRP1 in AML and CML patients with MDR.
Cases | AML no. (%) | CML no. (%) |
---|---|---|
Age | ||
<60 | 26 (89.7) | 16 (43.2) |
≥60 | 3 (10.3) | 21 (56.8) |
Gender | ||
Male | 17 (58.6) | 23 (62.2) |
Female | 12 (41.4) | 14 (37.8) |
≥Twofold higher levels versus patients without MDR | ||
B4GALT1 | 19 (65.5)* | 25 (67.6)* |
B4GALT2 | 2 (6.9) | 3 (8.1) |
B4GALT3 | 0 (0) | 4 (10.8) |
B4GALT4 | 0 (0) | 0 (0) |
B4GALT5 | 16 (55.2)* | 22 (59.5)* |
B4GALT6 | 0 (0) | 0 (0) |
B4GALT7 | 0 (0) | 0 (0) |
Abbreviations: AML, acute myeloid leukemia; CML, chronic myeloid leukemia; MDR, multidrug resistance
*P<0.05 versus patients without MDR