Table I.

Targeted cellular mechanisms in multiple myeloma. (Ocio et al, 2008)

Cell surface receptors	Signalling pathways	Cell cycle	UPR	Epigenetic
Activators of cell-death receptors	NFκB	CDK	HSP	Hypomethylating compounds
TKR	Farnesyl-transferase	Aurora-kinase	Proteasome	Deacetylase inhibitors
mAb against plasma cell antigens	MAPK mTOR Akt		Aggresome formation

CDK, cyclin-dependent kinase; HSP, heat shock protein; mAb, monoclonal antibodies; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; NFκB, nuclear factor kappa B inhibitors; TKR, tyrosine-kinase inhibitors; UPR, unfolded protein response inhibitors.