Figure 1. The relationship between biomarkers and joint hypermobility in the total cohort (a–c) and Non-Hand OA subgroups (d–e) of the CARRIAGE family.

a) Serum ln COMP (after adjustment for age) and Beighton score separated into 3 groups, no hypermobility (score 0), moderate hypermobility (score 1–3) and high hypermobility (score ≥4); b) Serum ln COMP by hypermobility status; c) Serum ln HA by hypermobility status. Analysis of participants without hand OA was based on d) clinical GOGO criteria (n=228: n=34 with and n=194 without joint hypermobility); or e) modified ACR criteria (n=233: n=34 with and n=199 without joint hypermobility). P value calculated by one-way ANOVA with Tukey multiple comparison (a), or two-sample t test (b–e). Box plots depict mean, 25^th and 75^th percentiles, and minimum and maximum. Hypermobility status defined by Beighton score <4 (Non-hypermobilty) or ≥4 (Hypermobility). COMP = cartilage oligomeric matrix protein, HA = hyaluronan, NS = non-significant.