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. Author manuscript; available in PMC: 2013 Jul 2.
Published in final edited form as: Arthritis Rheum. 2008 Dec;58(12):3854–3864. doi: 10.1002/art.24319

Table 1.

Summary of previous studies of osteoarthritis and articular hypermobility.

Study (reference) Country of origin or ethnic origin Study design Number with hypermobility/ Total n (%) Hypermobility Criteria used Relationship of joint hypermobility and OA
Scott et al 1979 (36) UK Clinical population; Age-matched OA-control 9/100(9%) Beighton score≥4 & left 2nd MCP joint In general:

  • OA”

    In specific:

  • hand OA

  • KneeOA
Bridges et al 1992 (3) USA Clinical observation 20/130(15%) Beighton score≥5 12 “OA”of 20 hypermobile patients
Jonsson et al 1995 (34) Iceland Established hand OA patients 19/100(19%) Beighton score≥4

  • CMC1 OA

  • DIP OA

  • PIP OA
Jonsson et al 1996 (35) Iceland Established thumb base female OA patients 17/50(34%) Beighton score≥4

  • DIP OA

  • PIP OA
Dolan et al 2003 (33) UK Postmenopausal community population 79/716(11%) Beighton score≥1

  • Knee OA
Kraus et al 2004 (32) Caucasian (UK & USA) OA sib-pairs family study 39/1043(3.7%) Beighton score≥4

  • PIP OA
Chen et al 2008-CARRIAGE family study Mixed Africa and Native American (USA) Extended family-based study 36/280(12.9%) Beighton score≥4

  • PIP OA,

  • Knee OA

  • Serum COMP

OA = osteoarthritis; “OA” means type of osteoarthritis not reported; COMP = cartilage oligomeric matrix protein CMC1 = carpometacarpal; DIP = distal interphalangeal; PIP = proximal interphalangeal; MCP = metacarpophalangeal

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