Table 4.
Clinical OA status by hypermobility status in the CARRIAGE family.
| OA Definitions | Hypermobility Group N (%) by OA Status | Non-Hypermobility Group N (%) by OA Status | P value | P value (adjusted for age and BMI) |
|---|---|---|---|---|
| Hand: GOGO Criteria (n=280 evaluated) | 1 (2.8%) | 42 (17.2%) | <0.01 | 0.02 |
| GOGO criterion 1 | 1 (2.8%) | 57 (23.4%) | <0.001 | <0.01 |
| GOGO criterion 2 | 5 (13.9%) | 60 (24.6%) | 0.13 | 0.3 |
| GOGO criterion 3 | 4 (11.1%) | 71 (29.1%) | 0.01 | 0.02 |
| Hand: Modified ACR Criteria (n=280 evaluated) | 1 (2.8%) | 36 (14.8%) | 0.02 | 0.05 |
| ACR criterion 1 | 2 (5.6%) | 68 (27.9%) | <0.005 | <0.005 |
| ACR criterion 2 | 2 (5.6%) | 39 (16.0%) | 0.06 | 0.14 |
| Knee: ACR criteria (n=115 evaluated) | 3 (12.0%) | 31 (34.4%) | 0.02 | 0.07 |
| Joint Site Involvement (n=280 evaluated) | mean ± SD # OA Joints | mean ± SD # OA Joints | ||
| DIPs | 0.22 ± 0.63 | 0.60 ± 1.35 | 0.13 | 0.18 |
| PIPs | 0.14 ± 0.49 | 1.01 ± 1.97 | <0.005 | 0.01 |
| CMC1 | 0.028 ± 0.17 | 0.14 ± 0.48 | 0.2 | 0.24 |
| DIPs+PIPs+CMC1 | 0.39 ± 0.99 | 1.75 ± 3.12 | <0.005 | 0.02 |
Hypermobility Group = Beighton score ≥4 (total n=36 in the hand examined group and n=25 in the knee examined group); Non-Hypermobility Group = Beighton score <4 (total n=244 in the hand examined group and n=90 in the knee examined group) GOGO and (modified) ACR criterion given in Table 2
P value by Likelihood ratio Chi-square test for OA definition; p value by Mann-Whitney test for joint sites; DIP = distal interphalangeal; PIP = proximal interphalangeal; CMC1 = carpometacarpal