AGS
|
Aicardi-Goutières syndrome, rare inherited autoimmune, inflammatory disorder caused by non-sense mutations in the samhd1, trex1 or rnaseh2a-c genes
|
| Cofilin |
actin severing factor regulating cellular F-actin polymerization states |
| Cortical actin |
F-actin layer underneath the plasma membrane providing a physical barrier to virus entry |
| CXCR4 |
chemokine receptor acting as entry co-receptor for HIV-1 with CXCR4-tropic Env |
| HIV |
human immunodeficiency virus, causative agent of AIDS |
| RT |
reverse transcription, characteristic step in the life cycle of retroviruses in which incoming genomic RNA is transcribed into DNA by the viral enzyme reverse transcriptase |
| SAMHD1 |
sterile alpha motif (SAM) and histidine/aspartic acid (HD) domain-containing protein 1, host cell deoxynucleoside triphosphate (dNTP) triphosphohydrolase |
| SIV |
simian immunodeficiency virus |
| TREX1 |
three prime repair exonuclease 1, 3′-5′ cellular exonuclease |
| Vpx |
viral protein X, encoded by most SIVs and HIV-2 strains, SAMHD1 antagonist |
| Vpr |
viral protein R, encoded by HIV-1 and some SIV strains |
| VSV-G |
glycoprotein of the vesicular stomatitis virus; can be incorporated into lentiviral particles to mediate cell entry in a CD4- and CXCR4-independent manner |
