Table 1.

Diarrhea Associated with WHO-Recommended HIV Regimens for ART-Naive Patients

Regimen		Source (author, year, journal)		Setting	Study duration (in weeks)	Diarrhea grade reported	N	Number of patients with diarrhea	Percentage of patients with diarrhea
AZT 3TC EFV	Tukei	2012	J Acquir Immune Defic Syndr	Uganda	Varied	Not reported	162	10	6%
	Currier	2008	Antivir Ther	Canada, European Union, USA	12	Grade 2–4	29	2	7%
	Tashima	2008	AIDS	Europe, North America	168	Grade 2–4	312	14	4%
	Castillo	2006	Drug Saf	Africa, Europe, North America, South America	≥48	Grade 1–4	325	58	18%
	Gallant	2006	N Engl J Med	France, Germany, Italy, Spain, United Kingdom, USA	48	Grade 2–4	254	10	4%
	DeJesus	2004	Clin Infec Dis	Argentina, Brazil, Canada, USA	48	Grade 1–4	272	26	10%
	DeJesus	2004	Clin Infec Dis	Argentina, Brazil, Canada, USA	48	Grade 1–4	273	18	7%
Total							1627	138	8%
AZT 3TC NVP	Tukei	2012	J Acquir Immune Defic Syndr	Uganda	Varied	Not reported	58	4	7%
	Podzamczer	2002	Antivir Ther	Argentina, Spain	52	Grade 1–4	72	0	0%
	Bernasconi	2001	Swiss Med Weekly	Switzerland	Not reported	Not reported	16	6	38%
Total							146	10	7%
TDF FTC EFV	Sax	2012	Lancet	North America	48	Mild, moderate, severe	352	66	19%
	Lennox	2009	Lancet	Australia, Brazil, Canada, Chile, Colombia, France, Germany, India, Italy, Mexico, Peru, Spain, Thailand, USA	48	Moderate to severe	282	8	3%
	DeJesus	2009	J Acquir Immune Defic Syndr	Puerto Rico, USA	48	Grade 1–4	203	16	8%
	DeJesus	2008	HIV Clin Trials	USA	24	Not reported	372	123	33%
	Gallant	2006	N Engl J Med	France, Germany, Italy, Spain, United Kingdom, USA	48	Grade 2–4	257	17	7%
Total							1466	230	16%
TDF 3TC EFV	DeJesus	2008	HIV Clin Trials	USA	24	Not reported	372	19	5%
	Markowitz	2007	J Acquir Immune Defic Syndr	Australia, Canada, Latin America, Thailand, USA	48	Mild, moderate, severe	38	4	11%
Total							410	23	6%
TDF 3TC NVP	N/A		N/A				N/A	N/A
TDF FTC NVP	N/A		N/A				N/A	N/A
Total weighted mean							3649	401	11%