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. 2013 Jun 21;2(3):e000134. doi: 10.1161/JAHA.113.000134

Figure 5.

Figure 5.

Effect of TDAG51 deficiency on atherosclerotic lesions in ApoE−/− mice. TDAG51−/−/ApoE−/− mice (dKO) and ApoE−/− control mice were fed standard chow diets for 25 or 40 weeks (n=8 to 9 per group). A and B, Aortic root sections were stained with hematoxylin/eosin, and mean atherosclerotic lesion size was determined. Significant reduction (*P<0.05) in lesion size was observed at both 25 and 40 weeks in dKO compared with ApoE−/− control groups. Black line demarcates lesion area. Scale bar=500 μm. C, Representative en face Oil Red O (ORO)‐stained aortas and quantitative assessment showed significant reduction (*P=0.0016) in lipid deposition in aortas from 40‐week‐old dKO mice compared with the control group. For quantitative data, results from 3 independent experiments are shown. D, Representative images are shown of necrotic core sizes in aortic root lesions of 25‐ and 40‐week‐old dKO and ApoE−/− mice (n=5). Red line demarcates necrotic core area. Scale bar=100 μm. E, Necrotic core sizes of 25‐ and 40‐week‐old dKO mice were smaller in aortic root lesions compared with their respective ApoE−/− control groups (n=5). Data are shown as mean necrotic core area±SE (*P<0.005). TDAG51 indicates T‐cell death‐associated gene 51; ApoE, apolipoprotein E; dKO, double knockout.