Table 1.
Lesion Composition of TDAG51−/−/ApoE−/− and ApoE−/− Mice
% Mac‐3 Staining | % SMA Staining | |||||||
---|---|---|---|---|---|---|---|---|
dKO | ApoE −/− | n | P | dKO | ApoE −/− | n | P | |
25 Weeks | 20.07 | 5.35 | 4 | NS | 3.31 | 2.38 | 5 | NS |
40 Weeks | 5.77 | 3.69 | 5 | NS | 0.79 | 0.42 | 5 | NS |
Lesions from 25‐ or 40‐week‐old TDAG51−/−/ApoE−/− (dKO) and ApoE−/− mice were sectioned and probed for Mac‐3 (macrophages) and SMA (smooth muscle actin). Macrophage or smooth muscle cell area was measured, and data are expressed as percentage of lesion area. TDAG51 indicates T‐cell death‐associated gene 51; ApoE, apolipoprotein E; dKO, double knockout; n, mouse number; NS, not significant.