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. 2013 Jun 21;2(3):e000150. doi: 10.1161/JAHA.113.000150

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© 2013 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley-Blackwell.

This is an Open Access article under the terms of the Creative Commons Attribution Noncommercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Figure 4. — Effects of ivabradine (iva) on the fibrosis‐related genes expression in dnNRSF‐Tg (Tg) mice. A through F, Relative levels of Col1a1 (A), Col3a1 (B), FN1 (C), MMP2 (D), MMP9 (E), and Tgfb1 (F) mRNA in hearts from 20‐week‐old WT and Tg mice treated with or without iva. n=4 for WT without iva, n=4 for WT with iva, n=5 for Tg without iva, and n=3 for Tg with iva. Mice treated without iva are indicated as cont. Kruskal–Wallis nonparametric ANOVA followed by the Bonferroni correction was used for the analysis. All data are shown as dot plots. NS indicates not significant; dnNRSF‐Tg, dominant‐negative form of neuron‐restrictive silencer factor transgenic mice; ANOVA, analysis of variance; WT, wild type; cont, control; Col1a1, collagen type1 α1; Col3a1, collagen type3 α 1; FN1, fibronectin 1; MMP2, matrix metallopeptidase 2, MMP9, matrix metallopeptidase 9; Tgfb1, transforming growth factor‐ β 1.