Table 3.

Echocardiographic Data in 24‐Week‐Old WT and HCN2‐Tg Mice Treated With Isoproterenol for 1 Week

	WT+Iso	HCN2‐Tg+Iso
LVDd, mm	3.09±0.18	3.14±0.21
LVDs, mm	1.68±0.21	1.66±0.33
FS, %	46.4±4.1	49.6±7.8

Values are means±SEM. Numbers of mice tested are n=5 for WT treated with isoproterenol and 4 for HCN2‐Tg treated with isoproterenol. The Mann–Whitney test was used for comparison between WT+Iso and HCN2‐Tg+Iso.WT indicates wild type; HCN2‐Tg, hyperpolarization‐activated cyclic nucleotide‐gated channel 2 transgenic mice; Iso, isoproterenol; LVDd, left ventricular diastolic dimension; LVDs, left ventricular systolic dimension; FS, fractional shortening.