Table 3.
Comparison of Baseline and Day 1 Values for Different Parameters Among TAC Mice
| Parameter | Baseline | Day 1 | Change (%) | n | P Value |
|---|---|---|---|---|---|
| Ki | 0.10 | 0.51 | 407.67 | 8 | 0.011 |
| Ejection fraction, % | 53.77 | 42.5 | −20.9 | 8 | 0.011 |
| HW/BW | 3.54 | 3.89 | 9.89 | 5 | NS |
| Wall thickness, mm | 0.9 | 1.0 | 11.1 | 5 | 0.043 |
| Heart rate, bpm | 406.8 | 470.8 | 15.7 | 5 | NS |
| LV systolic pressure, mm Hg | 83.95 | 119 | 41.8 | 3 | NS |
P values were obtained using the Wilcoxon signed rank test. Change (%) indicates average change from baseline to day 1 in each of the measured corresponding parameters; “n” indicates number of animals used in each of the measured corresponding parameters; TAC, transverse aortic constriction; HW/BM, heart weight to body weight ratio; LV, left ventricle.