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. Author manuscript; available in PMC: 2013 Jul 2.
Published in final edited form as: Ann Intern Med. 2013 Apr 2;158(7):515–525. doi: 10.7326/0003-4819-158-7-201304020-00003

Figure 2.

Figure 2

Relationship between dietary eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) consumption and plasma phospholipid EPA+DHA concentrations among 2,692 older US adults, evaluated using restricted cubic splines, and adjusted for age, sex, race, and education. Because the dietary questionnaire estimated only EPA+DHA (and not DPA), for comparability we evaluated circulating EPA+DHA (rather than EPA+DPA+DHA). Median circulating levels of EPA+DHA in the highest quintile were ~5 percent of total fatty acids. The solid line and shaded area represent the central estimate and 95% CIs, respectively. There was strong evidence for both an overall trend (P<0.001) and nonlinearity of this relationship (P<0.001).