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AdoMet catabolism. Excess AdoMet generated in the liver after a protein-rich meal is rapidly eliminated by the enzyme glycine N-methyltransferase (GNMT), which catalyzes the synthesis of methyl-glycine (sarcosine) from glycine. Sarcosine dehydrogenase (SDH) is a flavoprotein that catalyzes the oxidative demethylation of sarcosine to glycine. In this reaction, tetrahydrofolate (THF) is converted to 5,10-methyllenetrahydrofolate (5,10-MTHF).
