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. 2013 Jan 31;208(3):504–511. doi: 10.1093/infdis/jit042

Figure 2.

Figure 2.

VNI is more effective than posaconazole and ravuconazole in clearing Trypanosoma cruzi–infected cardiomyocytes. A, Comparative dose-dependent antiparasitic effects. Cardiomyocyte monolayers were infected with green fluorescent protein–expressing trypomastigotes for 24 hours and then treated with different concentrations of VNI, posaconazole (POS), ravuconazole (RAV), or dimethyl sulfoxide (DMSO). Parasite multiplication within monolayers was estimated by green fluorescent protein fluorescence (expressed in relative fluorescence units [RFU]) 72 hours after infection. Data represent the mean values ± SD of the results from triplicate samples. B, Fluorescence microscopic observation of T. cruzi multiplication inside cardiomyocytes treated with 7.5 nM of VNI, posaconazole, and ravuconazole 72 hours after infection. T. cruzi amastigotes are green, cardiomyocyte nuclei are blue, and cardiomyocyte actin myofibrils are red.