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17-DMAG has antitrypanosomal activity in vivo. Mice were infected with Trypanosoma brucei on day 0. Starting on day 1, they were treated once daily with vehicle or drug as indicated and then monitored for up to 30 days for survival (A) and parasitemia (average value for group; B) by visual analysis and hemocytometer counts of trypanosomes in tail snip blood samples. ip, intraperitoneally; og, by oral gavage; ×1, once; ×5, for 5 days.
